Migraine affects more than one billion people worldwide,^1-3 is the sixth most common and second most disabling disease,^{1, 4} and the top cause of years loss due to disability (YLD) for 15–49 year olds.⁴ In the United States, it is more common in women than men, and headache is the third leading cause of emergency department visits among premenopausal women,⁵ said Professor Buse.

Six different types of migraine

The International Classification of Headache Disorders version 3 (ICHD-3; ichd-3.org),⁶ describes six different types of migraine, explained Elizabeth Loder, Professor of Neurology, Harvard Medical School and Chief of the Division of Headache, Brigham and Women’s Hospital Boston MA. These types (for which there may be subtypes and subforms) are:

• migraine without aura (previously known as common migraine)
• migraine with aura (previously known as classic migraine)
• chronic migraine
• complications of migraine
• probable migraine
• episodic syndromes that may be associated with migraine.

Professor Loder commented that the ICHD-3 is a marked improvement on previous versions, but it is important to note that its biological validity is uncertain, and some characteristic features such as osmophobia, prodromal features and activating and relieving factors are missing.

ICHD-3 migraine without aura

Migraine without aura is often related to the menstrual cycle

A diagnosis of migraine without aura is based on at least five attacks of headache lasting 4–72  associated with:

• at least two of the following four characteristics — unilateral, pulsating, moderate or severe intensity, aggravated by routine physical activity
• nausea and/or vomiting or photophobia and phonophobia (fear of loud sounds)

If a patient falls asleep during an attack, the duration is recorded as the time to awakening.

ICHD-3 migraine with aura

Migraine with aura may be associated with prodromal and postdromal symptoms

A diagnosis of migraine with aura is based on at least two attacks associated with:

• one or more of fully reversible aura symptoms: visual, sensory, speech and/or language, motor, brainstem, or retinal— visual aura is the most common type, occurring in over 90% of patients
• at least three of the following six characteristics — at least one aura symptom spreading gradually over at least 5 minutes; two or more aura symptoms in succession; each individual aura symptom lasting 5–60 minutes (motor symptoms may last up to 72 hours); at least one unilateral aura symptom; at least one positive aura symptom (e.g. scintillations, pins and needles); headache accompanying or within 60 minutes after the aura

Prodromal symptoms — e.g. fatigue, difficulty in concentrating, neck stiffness, sensitivity to light and/or sound, nausea, blurred vision, yawning and pallor — may precede a migraine attack with aura hours or a day or two before the other symptoms.

Postdromal symptoms — most commonly fatigue and elated or depressed mood — may follow resolution of the headache and persist for up to 48 hours.

Migraine with brainstem aura is a subtype of migraine with aura

Migraine with brainstem aura, a subtype of migraine with aura, is diagnosed if there are at least two attacks of headache associated with:

• fully reversible visual, sensory, speech and/or speech/language symptoms, but no motor, brainstem or retinal symptoms
• at least two of the following seven fully reversible brainstem symptoms — dysarthria, vertigo, tinnitus, hypacusis, diplopia, ataxia, decreased level of consciousness
• at least two of the following four characteristics — at least one aura symptom spreading gradually over at least 5 minutes and/or two or more aura symptoms in succession; individual aura symptoms lasting 5–60 minutes; at least one unilateral aura symptom; headache accompanying or within 60 minutes after the aura

Autonomic symptoms accompany some of the headaches in up to 50% of patients with migraine

ICHD-3 chronic migraine

Chronic migraine is diagnosed when migraine-like or tension-type-like headache on at least 15 days/month for over 3 months are associated with:

• at least five attacks fulfilling the diagnostic criteria for migraine with or without aura

The most common cause of symptoms suggestive of chronic migraine is medication overuse

• the characteristics other than the duration fulfil the diagnostic criteria of migraine with or without aura or are believed by the patient to be migraine at onset and relieved by a “triptan” or “ergot” derivative on at least 8 days/month for over 3 months(Ref guideline)

Medication overuse is the most common cause of symptoms suggestive of chronic migraine, and around 50% of patients with an apparent diagnosis of chronic migraine revert to an episodic migraine type after drug withdrawal.

Earlier effective treatment of migraine results in less migraine-associated disability

Migraine is a neurological disorder involving nerve pathways and brain chemicals

The traffic light system of headache, which describes the associated disability of the migraine headache attack — green (“I can still go”), yellow (“I have to slow down”), red (“I have to stop”)⁷ — facilitates early effective treatment, said Professor Christine Lay, University of Toronto, Canada.

Professor Stephanie Nahas of Thomas Jefferson University, Philadelphia, PA, highlighted the importance of preventive treatment to:

• reduce attack frequency, severity, and duration
• improve responsiveness to treatment of acute attacks
• improve function and reduce disability and costs
• to prevent disease progression

Preventive lifestyle measures include regular sleep, exercise, and small meals, and avoidance of identifiable triggers (hormonal and those related to sleep, stress, exertion, and environment).

Meanwhile, migraine prevention trials are  evaluating benefit-risk profiles for newer calcitonin gene-related peptide antibodies compared to currently recommended therapies for migraine prevention.⁸